KU-60019 |CAS:925701-46-8 Probechem Biochemicals

Chemical Structure : KU-60019

CAS No.: 925701-46-8

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KU-60019 (KU60019;KU 60019)

货号: PC-42876Not For Human Use, Lab Use Only.

KU-60019 is an improved analogue of KU-55933, and is a potent, specific inhibitor of ATM kinase with IC50 of 6.3 nM, 270- and 1,600-fold selectivity over DNA-PKcs and ATR.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KU-60019 is an improved analogue of KU-55933, and is a potent, specific inhibitor of ATM kinase with IC50 of 6.3 nM, 270- and 1,600-fold selectivity over DNA-PKcs and ATR.
KU-60019 blocks radiation-induced phosphorylation of key ATM targets in human glioma cells, which is 10-fold more effective than KU-55933.
KU-60019 reduces basal S473 AKT phosphorylation and inhibits glioma cell migration and invasion in vitro.
KU-60019 preferentially sensitizes p53-mutant glioma to ionizing radiation in orthotopic xenograft models of GBM.

物理化学性质&存储条件

分子量	547.6651
分子式	C30H33N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-

参考文献

1. Golding SE, et al. Mol Cancer Ther. 2009 Oct;8(10):2894-902.

2. Gamper AM, et al. J Biol Chem. 2012 Apr 6;287(15):12445-54.

3. Biddlestone-Thorpe L, et al. Clin Cancer Res. 2013 Jun 15;19(12):3189-200.

4. Golding SE, et al. Cell Cycle. 2012 Mar 15;11(6):1167-73.

KU-60019 (KU60019;KU 60019)

生物&药学活性

物理化学性质&存储条件

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KU-60019 (KU60019;KU 60019)

生物&药学活性

物理化学性质&存储条件

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