KU-55933 |CAS:587871-26-9 Probechem Biochemicals

Chemical Structure : KU-55933

CAS No.: 587871-26-9

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KU-55933 (KU 55933;KU55933)

货号: PC-42831Not For Human Use, Lab Use Only.

KU-55933 (KU55933) is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM, >100-fold selectivity against other members of the PIKK family kinases.

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25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg	￥4880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

KU-55933 (KU55933) is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM, >100-fold selectivity against other members of the PIKK family kinases.
KU-55933 inhibits ATM-dependent p53 Ser15 phosphorylation in U2OS osteosarcoma cells with IC50 of 0.3 uM.
KU-55933 sensitizes the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin.
KU-55933 also suppresses the replication of both wild-type and drug-resistant HIV-1 by sensitizing cells to retrovirus-induced cell death.

物理化学性质&存储条件

分子量	395.4946
分子式	C21H17NO3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 80 mg/mL (Need ultrasonic)
Chemical Name/SMILES	4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-

参考文献

1. Hickson I, et al. Cancer Res. 2004 Dec 15;64(24):9152-9.

2. Lau A, et al. Nat Cell Biol. 2005 May;7(5):493-500.

3. Soriani A, et al. Blood. 2009 Apr 9;113(15):3503-11.

KU-55933 (KU 55933;KU55933)

生物&药学活性

物理化学性质&存储条件

参考文献

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KU-55933 (KU 55933;KU55933)

生物&药学活性

物理化学性质&存储条件

参考文献

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