KU-32 |CAS:956498-70-7 Probechem Biochemicals

Chemical Structure : KU-32

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KU-32 (KU 32;KU32)

货号: PC-60660Not For Human Use, Lab Use Only.

KU-32 is a novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70.

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生物&药学活性

KU-32 is a novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70.
KU-32 protects against neuronal death induced by amyloid β-peptide with minimally cytotoxic to primary cortical neurons.
KU-32 significantly increases the expression of Hsp70 in MCF7 cells at 10 nM, decreases neurodegeneration of non-myelinated or myelinated sensory neurons in vitro and attenuates the pathophysiological progression of DPN in mice.

物理化学性质&存储条件

分子量	407.419
分子式	C20H25NO8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydro-2H-pyran-2-yloxy]-8-methyl-2-oxo-2H-chromen-3-yl}acetamide

参考文献

1. Ma J, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):281-92.

2. Urban MJ, et al. ASN Neuro. 2010 Aug 11;2(4):e00040.

KU-32 (KU 32;KU32)

生物&药学活性

物理化学性质&存储条件

参考文献

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KU-32 (KU 32;KU32)

生物&药学活性

物理化学性质&存储条件

参考文献

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