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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-KU-177
KU-177

Chemical Structure : KU-177

CAS No.: 1160952-43-1

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KU-177 (KU177)

货号: PC-72658Not For Human Use, Lab Use Only.

KU-177 (KU-177) is a selective small molecule inhibitor of Hsp90 cochaperone AHSA1 (Aha1 ,activator of Hsp90 ATPase homolog 1, Activator of HSP90 ATPase Activity 1), inhibits interaction between Hsp90 and Aha1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KU-177 (KU-177) is a selective small molecule inhibitor of Hsp90 cochaperone AHSA1 (Aha1 ,activator of Hsp90 ATPase homolog 1, Activator of HSP90 ATPase Activity 1), inhibits interaction between Hsp90 and Aha1.
    KU-177 inhibits Hsp90-mediated luciferase refolding activity in PC3-MM2 cell with IC50 of 2 uM.
    KU-177 inhibits Aha1 enhancement of Hsp90-mediated tau aggregation, increased soluble, phosphorylated tau in cultured cells.
    AHSA1-K137 is identified as the site-specific targeting of KU-177 and Bufalin.
    KU-177 decreases MM cell proliferation and proteasome inhibitor (PI) resistance induced by AHSA1/HSP90 in vitro (H929 cell IC50=25.8 uM).
    KU-177 (1mg/kg, twice per week) extends the survival of 5TMM3VT MM mice when combined with Bortezomib (BTZ) (1mg/kg, twice per week).

    物理化学性质&存储条件

    分子量 489.48
    分子式 C27H23NO8
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate

    参考文献

    1. Shelton LB, et al. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9707-9712.

    2. Gu C, et al. J Exp Clin Cancer Res. 2022 Jan 6;41(1):11.

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