KU-0063794 |CAS:938440-64-3 Probechem Biochemicals

Chemical Structure : KU-0063794

CAS No.: 938440-64-3

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KU-0063794 (KU 0063794;KU0063794)

货号: PC-45851Not For Human Use, Lab Use Only.

KU-0063794 is a potent, specific, cell permeant inhibitor of mTOR with IC50 of 10 nM for both mTORC1 and mTORC2.

规格	价格	库存
10 mg	￥1080	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

KU-0063794 is a potent, specific, cell permeant inhibitor of mTOR with IC50 of 10 nM for both mTORC1 and mTORC2.
KU-0063794 displays no activity against 76 other protein kinases or seven lipid kinases, including class 1 PI3Ks (>1,000-fold).
KU-0063794 suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK, also inhibits phosphorylation of the T-loop Thr308 of Akt, induces complete dephosphorylation of 4E-BP1 in HEK-293 cells.
KU-0063794 suppresses cell growth and induces G1-cell cycle arrest in both wild-type and mLST8 deficient MEFs.

物理化学性质&存储条件

分子量	465.5447
分子式	C25H31N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenemethanol, 5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-, rel-

参考文献

1. García-Martínez JM, et al. Biochem J. 2009 Jun 12;421(1):29-42.

2. Malagu K, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5950-3.

3. Syed F, et al. J Invest Dermatol. 2013 May;133(5):1340-50.

KU-0063794 (KU 0063794;KU0063794)

生物&药学活性

物理化学性质&存储条件

参考文献

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KU-0063794 (KU 0063794;KU0063794)

生物&药学活性

物理化学性质&存储条件

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