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首页-小分子抑制剂&激动剂-Others-Protein Kinase G (PKG)-KT-5823
KT-5823

Chemical Structure : KT-5823

CAS No.: 126643-37-6

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KT-5823 (KT5823)

货号: PC-63045Not For Human Use, Lab Use Only.

KT-5823 is a potent, highly specific PKG (cGMP-dependent protein kinase) inhibitor with Ki of 0.234 uM.

规格 价格 库存 数量
100 ug ￥2480 In stock
500 ug ￥5980 In stock
1 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KT-5823 is a potent, highly specific PKG (cGMP-dependent protein kinase) inhibitor with Ki of 0.234 uM.
KT-5823 also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively.
KT-5823 arresst cells at a later time that is approximately 6 h after the G0/G1 boundary.

物理化学性质&存储条件

分子量 495.525
分子式 C29H25N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, [9S-(9α,10β,12α)]-

参考文献

1. Gadbois DM, et al. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30.

2. Burkhardt M, et al. J Biol Chem. 2000 Oct 27;275(43):33536-41.

3. Beyer S, et al. Endocrinology. 2011 Mar;152(3):782-92.

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