KT-531 | HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : KT-531

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KT-531 (KT531)

货号: PC-72739Not For Human Use, Lab Use Only.

KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity.

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生物&药学活性

KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms.
KT-531 demonstrated biological potency in multiple hematological cancer cell models (acute myeloid leukemia (AML), PTCL, and T-cell acute lymphoblastic leukemia (T-ALL)) and limited cytotoxicity in nonmalignant cell types as well as no observable toxicity in vivo (CD-1 mice).
KT-531 exhibited strong potency (IC50=0.42 μM) in the T-ALL/T-PLL-like cell line SUP-T11, demonstrated higher cytotoxicity than Nexturastat in MV4-11 cancer cells (IC50=0.42 uM versus 1.68 uM).
KT-531 showed high synergy with chemotherapeutic agents idasanutlin, bendamustine, and venetoclax in T-PLL patient samples.
KT-531 is the first HDAC6 inhibitor to show efficacy in T-PLL patient samples.

物理化学性质&存储条件

分子量	418.363
分子式	C17H14F4N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 4-[[cyclopropyl[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]-N-hydroxy-

参考文献

1. Krimo Toutah, et al. J Med Chem. 2021 Jun 24;64(12):8486-8509.

KT-531 (KT531)

生物&药学活性

物理化学性质&存储条件

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KT-531 (KT531)

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物理化学性质&存储条件

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