KT-172 |CAS:1402612-56-9 Probechem Biochemicals

Chemical Structure : KT-172

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KT-172 (KT172)

货号: PC-61839Not For Human Use, Lab Use Only.

KT-172 is a potent, selective inhibitor of DAGLβ with IC50 of 60 nM.

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生物&药学活性

KT-172 (KT172) is a potent, selective inhibitor of DAGLβ with IC50 of 60 nM.
KT-172 displays selectivity over DAGLα, and negligible activity against other key enzymes involved in endocannabinoid signaling, including FAAH, MAGL, and ABHD11.
KT-172 disrupts the lipid network involved in macrophage inflammatory responses, lowering 2-AG, as well as arachidonic acid and eicosanoids in mouse peritoneal macrophages.
KT-172 possesses one remaining off-target ABHD6 (IC50=5 nM).

物理化学性质&存储条件

分子量	452.55
分子式	C28H28N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-Benzylpiperidin-1-yl)(4-(2'-methoxy-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)methanone

参考文献

1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007.

KT-172 (KT172)

生物&药学活性

物理化学性质&存储条件

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KT-172 (KT172)

生物&药学活性

物理化学性质&存储条件

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