KT-109 | DAGLβ inhibitor | Probechem Biochemicals

Chemical Structure : KT-109

CAS No.: 1402612-55-8

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KT-109 (KT109)

货号: PC-61838Not For Human Use, Lab Use Only.

KT-109 (KT109) is a potent, selective inhibitor of DAGLβ with IC50 of 42 nM, displays about 60-fold selectivity over DAGLα.

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10 mg	￥1380	In stock
25 mg	￥2480	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

KT-109 (KT109) is a potent, selective inhibitor of DAGLβ with IC50 of 42 nM, displays about 60-fold selectivity over DAGLα.
KT-109 shows negligible activity against other key enzymes involved in endocannabinoid signaling, including FAAH, MAGL and ABHD11.
KT-109 disrupts the lipid network involved in macrophage inflammatory responses, lowering 2-AG, as well as arachidonic acid and eicosanoids in mouse peritoneal macrophages.
KT-109 reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain; possesses one remaining off-target ABHD6 (IC50=16 nM).

物理化学性质&存储条件

分子量	422.5
分子式	C27H26N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[2-(phenylmethyl)-1-piperidinyl]-methanone

参考文献

1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007.

2. Wilkerson JL, et al. Br J Pharmacol. 2016 May;173(10):1678-92.

3. Shin M, et al. Mol Pharm. 2017 Sep 13. doi: 10.1021/acs.molpharmaceut.7b00657.

KT-109 (KT109)

生物&药学活性

物理化学性质&存储条件

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KT-109 (KT109)

生物&药学活性

物理化学性质&存储条件

参考文献

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