KSQ-4279 (RO7623066) | USP1 inhibitor | Probechem Biochemicals

Chemical Structure : KSQ-4279

CAS No.: 2446480-97-1

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KSQ-4279 (KSQ4279, RO7623066)

货号: PC-73318Not For Human Use, Lab Use Only.

KSQ-4279 (RO7623066) is a potent, selective, first-in-class inhibitor of USP1, shows anti-proliferative effects in a subset of cell lines, including mutations in BRCA1/2.

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10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

KSQ-4279 (RO7623066) is a potent, selective, first-in-class inhibitor of USP1 with Ki of 1.2 nM, shows anti-proliferative effects in a subset of cell lines, including mutations in BRCA1/2.
KSQ-4279 has a unique mode of allosteric binding to USP1 and a high degree of selectivity over other family members.
USP1 is a protein regulating DNA damage response (DDR).
KSQ-4279 demonstrated efficacy both as a single agent and in combination with PARP inhibitors across multiple BRCA/HRD xenograft model.

物理化学性质&存储条件

分子量	534.547
分子式	C27H25F3N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-Cyclopropyl-6-methoxypyrimidin-5-yl)-1-(4-(1-isopropyl-4-(trifluoromethyl)-1H-imidazol-2-yl)benzyl)-1H-pyrazolo[3,4-d]pyrimidine

参考文献

1. Sol Shenker, et al. Cancer Res (2021) 81 (13_Supplement): 1337.

KSQ-4279 (KSQ4279, RO7623066)

生物&药学活性

物理化学性质&存储条件

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KSQ-4279 (KSQ4279, RO7623066)

生物&药学活性

物理化学性质&存储条件

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