KSP-IA | KSP inhibitor | Probechem Biochemicals

Chemical Structure : KSP-IA

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KSP-IA (KSP inhibitor)

货号: PC-70049Not For Human Use, Lab Use Only.

KSP-IA is a potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KSP-IA is a potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM.
KSP-IA has no ihibitory activity toward other kinesins, includin CENP-E, MKLP-1, KIF-3A, and uKHC (IC50>50 uM).
KSP-IA induces the formation of monoastral spindles, causes mitotic arrest in a dose-dependent manner (EC50=30 nM) in A2780 ovarian carcinoma cells.
KSP-IA sustained KSP inhibition activates the proapoptotic protein, Bax, and both activation of the spindle checkpoint and subsequent mitotic slippage are required for Bax activation.

物理化学性质&存储条件

分子量	356.417
分子式	C21H22F2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl)-3-methylbutan-1-one

参考文献

1. Tao W, et al. Cancer Cell. 2005 Jul;8(1):49-59.