KSI-3716 | c-MYC inhibitor | Probechem Biochemicals

Chemical Structure : KSI-3716

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KSI-3716 (KSI 3716)

货号: PC-38693Not For Human Use, Lab Use Only.

KSI-3716 is a small molecule c-MYC inhibitor that blocks c-MYC/MAX binding to target gene promoters, inhibits c-MYC mediated transcriptional activity at concentrations as low as 1 uM.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KSI-3716 is a small molecule c-MYC inhibitor that blocks c-MYC/MAX binding to target gene promoters, inhibits c-MYC mediated transcriptional activity at concentrations as low as 1 uM.
KSI-3716 markedly decreased the expression of c-MYC target genes, such as cyclin D2, CDK4 and hTERT, exerted cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis.
KSI-3716 (5 mg/kg) significantly suppressed tumor growth with minimal systemic toxicity.
KSI-3716 combined with gemcitabine inhibited gemcitabine-resistant cell proliferation to a great extent than each drug alone both in vitro and in vivo.

物理化学性质&存储条件

分子量	426.091
分子式	C17H11BrCl2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Acetyl-8-bromo-5-chloro-2-[(4-chlorophenyl)amino]-4(1H)-quinolinone

参考文献

1. Jeong KC, et al. J Urol. 2014 Feb;191(2):510-8.

2. Seo HK, et al. Oncotarget. 2014 Jan 30;5(2):326-37.

KSI-3716 (KSI 3716)

生物&药学活性

物理化学性质&存储条件

参考文献

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KSI-3716 (KSI 3716)

生物&药学活性

物理化学性质&存储条件

参考文献

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