KS100 | ALDH inhibitor | Probechem Biochemicals

Chemical Structure : KS100

CAS No.: 2408477-54-1

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KS100 (ALDH inhibitor KS100, KS 100)

货号: PC-38166Not For Human Use, Lab Use Only.

ALDH inhibitor KS100 (KS100) is a novel, potent, multi-isoform ALDH inhibitor with IC50 of 207/1410/240 nM for ALDH1A1/ALDH2/ALDH3A1, respectively.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

ALDH inhibitor KS100 (KS100) is a novel, potent, multi-isoform ALDH inhibitor with IC50 of 207/1410/240 nM for ALDH1A1/ALDH2/ALDH3A1, respectively.
KS100 was mitigated by development of a nanoliposomal formulation, called NanoKS100. NanoKS100 was 5-fold more selective for killing melanoma cells compared with normal human fibroblasts.
Inhibition by KS100 significantly reduced total cellular ALDH activity to increase reactive oxygen species generation, lipid peroxidation, and accumulation of toxic aldehydes leading to apoptosis and autophagy.

物理化学性质&存储条件

分子量	564.09
分子式	C17H14Br3N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamimidothioic acid, [4-[(5,7-dibromo-2,3-dihydro-2,3-dioxo-1H-indol-1-yl)methyl]phenyl]methyl ester, hydrobromide (1:1)

参考文献

1. Dinavahi SS, et al. Mol Cancer Ther. 2020 Feb;19(2):447-459.

KS100 (ALDH inhibitor KS100, KS 100)

生物&药学活性

物理化学性质&存储条件

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KS100 (ALDH inhibitor KS100, KS 100)

生物&药学活性

物理化学性质&存储条件

参考文献

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