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首页-小分子抑制剂&激动剂-Tyrosine Kinase-BTK-KS-99
KS-99

Chemical Structure : KS-99

CAS No.: 1344698-28-7

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KS-99 (KS99;KS 99)

货号: PC-70205Not For Human Use, Lab Use Only.

KS-99 (KS99) is a novel dual inhibitor of BTK and tubulin polymerization.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KS-99 (KS99) is a novel dual inhibitor of BTK and tubulin polymerization; interacts directly with the catalytic domain of BTK and inhibits phosphorylation at the Y223 residue and kinase activities; reduces the cell viability of MM and CD138+ cells (IC50=0.5-1 uM); inhibits the in vivo tumor growth of MM cells through the inhibition of BTK and tubulin.

    物理化学性质&存储条件

    分子量 466.147
    分子式 C17H10Br2N2O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5,7-dibromo-1-(4-(thiocyanatomethyl)benzyl)indoline-2,3-dione

    参考文献

    1. Pandey MK, et al. Exp Hematol. 2017 Jun 22. pii: S0301-472X(17)30233-3.

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