KS-40070 | DYRK1B inhibitor | Probechem Biochemicals

Chemical Structure : KS-40070

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KS-40070 (KS40070)

货号: PC-25352Not For Human Use, Lab Use Only.

KS-40070 is a potent, selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with IC50 of 18 nM, with no inhibition on human DYRK2 (IC50>10 uM).

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生物&药学活性

KS-40070 is a potent, selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with IC50 of 18 nM, with no inhibition on human DYRK2 (IC50>10 uM).
KS-40070 (10 uM) exhibits anti-adipogenesis effect in 3T3-L1 cells and ADMSCs, effectively inhibits lipid droplet accumulation.
KS-40070 (5 uM) reduces the expression of DYRK1B and other adipogenesis transcription factors, such as PPARγ and C/EBPα, in a dose-dependent manner and adipocyte-specific markers are also effectively decreased.
KS-40070 inhibits the nuclear-cytoplasmic translocation of FOXO1A through the inactivation of Akt.
KS-40070 suppressed body weight gain, food consumption, serum lipid levels, and adipose tissue mass in DIO mice.

物理化学性质&存储条件

分子量	358.40
分子式	C21H18N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-(4-methoxyphenyl)-1H-pyrazolo [3,4-b]pyridin-5-yl) phenyl)acetamide

参考文献

1. Areum Park, et al. Bioorg Med Chem Lett. 2021 Sep 1:47:128226.

2. Kang S, et al. Front Pharmacol. 2025 Jul 29;16:1645033.

KS-40070 (KS40070)

生物&药学活性

物理化学性质&存储条件

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KS-40070 (KS40070)

生物&药学活性

物理化学性质&存储条件

参考文献

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