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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-KRpep-2d
KRpep-2d

Chemical Structure : KRpep-2d

CAS No.: 2098181-84-9

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KRpep-2d (Ac-RRRRCPLYISYDPVCRRRR-NH2)

货号: PC-38328Not For Human Use, Lab Use Only.

KRpep-2d (Ac-RRCPLYISYDPVCRR-NH2) is a potent, selective, cell-membrane permeable, cyclic peptide inhibitor of K-Ras(G12D) with IC50 of 1.6 nM, >10-fold selectivity over WT and G12C KRas.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KRpep-2d (Ac-RRCPLYISYDPVCRR-NH2) is a potent, selective, cell-membrane permeable, cyclic peptide inhibitor of K-Ras(G12D) with IC50 of 1.6 nM, >10-fold selectivity over WT and G12C KRas.
KRpep-2d significantly suppressed ERK-phosphorylation, downstream of K-Ras(G12D), along with A427 cancer cell proliferation at 30 μM peptide concentration.

物理化学性质&存储条件

分子量 2561.01
分子式 C108H182N44O25S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in PBS (25.6 mg/mL)
Chemical Name/SMILES

Ac-RRRRCPLYISYDPVCRRRR-NH2 (disulfide bridge: Cys5-Cys15)

参考文献

1. Sakamoto K, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):605-611.

2. Niida A, et al. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761.

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