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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-KRas-IN-1
KRas-IN-1

Chemical Structure : KRas-IN-1

CAS No.: 84783-01-7

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KRas-IN-1

货号: PC-45517Not For Human Use, Lab Use Only.

A chemical fragment hit that binds to K-Ras (G12D) with affinities of 1.3-2 mM.

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50 mg ￥12000 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A chemical fragment hit that binds to K-Ras (G12D) with affinities of 1.3-2 mM; binds to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.

物理化学性质&存储条件

分子量 207.292
分子式 C11H13NOS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 28 mg/mL
Chemical Name/SMILES

Methanethione, (2-hydroxyphenyl)-1-pyrrolidinyl-

参考文献

1. Sun Q, et al. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-3.

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