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首页-小分子抑制剂&激动剂-GPCR-Melanin-concentrating Hormone Receptor (MCHR)-KRX-104130
KRX-104130

Chemical Structure : KRX-104130

CAS No.: 1332364-25-6

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KRX-104130 (KRX104130)

货号: PC-22854Not For Human Use, Lab Use Only.

KRX-104130 is a potent melanin-concentrating hormone receptor 1 (MCHR1) antagonist with IC50 of 0.02 uM, shows no cardiotoxicity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KRX-104130 is a potent melanin-concentrating hormone receptor 1 (MCHR1) antagonist with IC50 of 0.02 uM, shows no cardiotoxicity.
KRX-104130 increased the expression of low-density lipoprotein receptor (LDLR), which induced cholesterol reduction in the gene expression analysis.
KRX-104130 showed a protective effect by reducing hepatic lipid accumulation, liver injury, and histopathological changes in NASH mouse model.

物理化学性质&存储条件

分子量 466.49
分子式 C24H24F2N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(1-((1H-indol-2-yl)methyl)piperidin-4-yl)-3-(6,7-difluoro-3-methoxyquinoxalin-2-yl)urea

参考文献

1. Lim G, et al. Int J Mol Sci. 2022 Mar 30;23(7):3807.

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