KRP-6 | MIF inhibitor | Probechem Biochemicals

Chemical Structure : KRP-6

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KRP-6 (MIF inhibitor KRP-6)

货号: PC-21293Not For Human Use, Lab Use Only.

KRP-6 is a potent and highly selective macrophage migration inhibitory factor (MIF) ketonase inhibitor with IC50 of 4.31 uM, significantly reduces MIF-induced neutrophil migration.

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生物&药学活性

KRP-6 is a potent and highly selective macrophage migration inhibitory factor (MIF) ketonase inhibitor with IC50 of 4.31 uM, significantly reduces MIF-induced neutrophil migration.
KRP-6 does not affect MIF enolase activity.
KRP-6 prevents M1 macrophage polarization and reduces ROS production in IFN-γ-treated cells.
KRP-6 improves mitochondrial bioenergetics by ameliorating basal respiration, ATP production, coupling efficiency and maximal respiration in LPS+IFN-γ-treated cells.
KRP-6 also reduces glycolytic flux in M1 macrophages.

物理化学性质&存储条件

分子量	266.30
分子式	C17H14O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	E-3-(2-methoxybenzylidene)chroman-4-one

参考文献

1. Vámos E, et al.Antioxidants (Basel). 2023 Sep 22;12(10):1790.

KRP-6 (MIF inhibitor KRP-6)

生物&药学活性

物理化学性质&存储条件

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KRP-6 (MIF inhibitor KRP-6)

生物&药学活性

物理化学性质&存储条件

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