KRN-633 | VEGFR-2 inhibitor | Probechem Biochemicals

Chemical Structure : KRN-633

CAS No.: 286370-15-8

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KRN-633 (KRN 633, KRN633)

货号: PC-42875Not For Human Use, Lab Use Only.

KRN-633 is a potent, selective VEGFR-2 inhibitor that inhibist the phosphorylation of VEGFR-2 with IC50 of 1.16 nM, also inhibits VEGFR-1, c-Kit and PDGFR-β with IC50 of 11.7, 8.01 and 130 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

KRN-633 is a potent, selective VEGFR-2 inhibitor that inhibist the phosphorylation of VEGFR-2 with IC50 of 1.16 nM, also inhibits VEGFR-1, c-Kit and PDGFR-β with IC50 of 11.7, 8.01 and 130 nM.
KRN-633 does not inhibits the phosphorylation of FGFR-1, EGFR, or c-Met at 10 uM.
KRN-633 blocks the activation of mitogen-activated protein kinases by VEGF, inhibits VEGF-driven proliferation of HUVECs with IC50 of 14.9 nM.
KRN-633 inhibits tumor growth in several in vivo tumor xenograft models with diverse tissue origins, including lung, colon, and prostate, in athymic mice and rats.

物理化学性质&存储条件

分子量	416.8582
分子式	C20H21ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl-

参考文献

1. Matsunaga N, et al. Mol Cancer Ther. 2006 Jan;5(1):80-8.

2. Wada Y, et al. J Pharmacol Sci. 2010;112(3):290-8.

3. Morita A, et al. Exp Eye Res. 2014 Mar;120:127-37.

4. Nakamura K, et al. Mol Cancer Ther. 2004 Dec;3(12):1639-49.

KRN-633 (KRN 633, KRN633)

生物&药学活性

物理化学性质&存储条件

参考文献

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KRN-633 (KRN 633, KRN633)

生物&药学活性

物理化学性质&存储条件

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