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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-KRIBB11
KRIBB11

Chemical Structure : KRIBB11

CAS No.: 342639-96-7

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KRIBB11 (KRIBB-11;KRIBB 11)

货号: PC-42278Not For Human Use, Lab Use Only.

KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM.

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM.
KRIBB11 inhibits HSF1 downstream target proteins HSP70 and HSP72 synthesis, induces growth arrest and apoptosis in HCT-116 cells, inhibits HSF1-dependent recruitment of p-TEFb to the hsp70 promoter.
KRIBB11 inhibits tumor growth without body weight loss in mice model.

物理化学性质&存储条件

分子量 284.27338
分子式 C13H12N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 27 mg/mL
Chemical Name/SMILES

2,6-Pyridinediamine, N2-1H-indazol-5-yl-N6-methyl-3-nitro-

参考文献

1. Yoon YJ, et al. J Biol Chem. 2011 Jan 21;286(3):1737-47.

2. Kang MJ, et al. Biochem Biophys Res Commun. 2017 Oct 21;492(3):304-309.

3. Carpenter RL, et al. Oncotarget. 2017 May 22;8(43):73947-73963.

4. Samarasinghe B, et al. Biochem Pharmacol. 2014 Feb 1;87(3):445-55.

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