KRAS-Q61X inhibitor compound 1

Chemical Structure : KRAS-Q61X inhibitor compound 1

加入收藏

货号: PC-27627Not For Human Use, Lab Use Only.

KRAS-Q61X inhibitor compound 1 is a specific small molecule ligand of KRAS-Q61X (X = H, L, K, R), selectively activates GTP hydrolysis of KRAS-Q61X mutants.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

KRAS-Q61X inhibitor compound 1 is a specific small molecule ligand of KRAS-Q61X (X = H, L, K, R), selectively activates GTP hydrolysis of KRAS-Q61X mutants.
KRAS-Q61X inhibitor compound 1 does not rescue the hydrolysis of HRAS-Q61R or NRAS-Q61R.
KRAS-Q61X inhibitor compound 1 does not directly engage HRAS and NRAS.

物理化学性质&存储条件

分子量	680.74
分子式	C37H35F3N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(8-((1H-imidazol-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol

参考文献

1. Ye-Cheng Wang, et al. Nat Chem Biol. 2026 Aug 12. doi: 10.1038/s41589-026-02291-1.