KR-62436 |CAS:761414-79-3 Probechem Biochemicals

Chemical Structure : KR-62436

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KR-62436 (KR62436)

货号: PC-35918Not For Human Use, Lab Use Only.

KR-62436 (KR62436) is a potent, selective DPP4 inhibitor with IC50 of 0.78, 0.49, 0.14 uM for rat plasma, porcine kidney, human DPP4 (Caco-2), respectively.

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生物&药学活性

KR-62436 (KR62436) is a potent, selective DPP4 inhibitor with IC50 of 0.78, 0.49, 0.14 uM for rat plasma, porcine kidney, human DPP4 (Caco-2), respectively.
KR-62436 completely inhibits DPP-IV-mediated degradation of GLP-1 in vitro at 10 uM, exhibits selectivity against several proteases including proline-specific protease.
KR-62436 promotes primary tumor growth and lung metastasis in a 4T1 tumor allograft mouse model, also shows anti-hyperglycemic activity in vivo.

物理化学性质&存储条件

分子量	297.322
分子式	C14H15N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile

参考文献

1. Kim KR, et al. Eur J Pharmacol. 2005 Jul 25;518(1):63-70.

2. Yang F, et al. Cancer Res. 2018 Dec 24. pii: canres.0620.2018. doi: 10.1158/0008-5472.CAN-18-0620.

KR-62436 (KR62436)

生物&药学活性

物理化学性质&存储条件

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KR-62436 (KR62436)

生物&药学活性

物理化学性质&存储条件

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