KR-33028 |CAS:861218-37-3 Probechem Biochemicals

Chemical Structure : KR-33028

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KR-33028 (KR33028)

货号: PC-35053Not For Human Use, Lab Use Only.

KR-33028 is a potent, highly selective NHE1 inhibitor with IC50 of 2.59 uM.

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250 mg		Get quote

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生物&药学活性

KR-33028 is a potent, highly selective NHE1 inhibitor with IC50 of 2.59 uM.
KR-33028 significantly decreases hypoxia-induced necrotic cell death and apoptotic cell death in H9c2 cells at 1-10 uM.
KR-33028 significantly inhibits hypoxia-induced increases in cytosolic and mitochondrial Ca2+ level and cytochrome c release, and recovered hypoxia-induced Delta psi(m) reduction.
KR-33028 demonstrates potent cardioprotective effects with minimal toxicity in perfused rat hearts.

物理化学性质&存储条件

分子量	244.272
分子式	C11H8N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-cyano-N-(diaminomethylene)benzo[b]thiophene-2-carboxamide

参考文献

1. Jung YS, et al. Eur J Pharmacol. 2006 Mar 27;535(1-3):220-7.

2. Kim J, et al. Eur J Pharmacol. 2007 Jul 12;567(1-2):131-8.

3. Kim H, et al. Arch Pharm Res. 2005 Nov;28(11):1287-92.

4. Lee BK, et al. Brain Res. 2009 Jan 12;1248:22-30.

KR-33028 (KR33028)

生物&药学活性

物理化学性质&存储条件

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KR-33028 (KR33028)

生物&药学活性

物理化学性质&存储条件

参考文献

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