KR-32570 |CAS:852146-75-9 Probechem Biochemicals

Chemical Structure : KR-32570

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KR-32570 (KR32570)

货号: PC-35054Not For Human Use, Lab Use Only.

KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM.

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生物&药学活性

KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM.
KR-32570 significantly and concentration dependently improves cardiac contractile function and severe contracture in conjunction with causing a marked reduction in lactate dehydrogenase release at 1-10 uM.
KR-32570 possesses potent cardioprotective effects in perfused rat hearts.

物理化学性质&存储条件

分子量	293.707
分子式	C13H12ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylidene)furan-2-carboxamide

参考文献

1. Lee BH, et al. Eur J Pharmacol. 2005 Mar 28;511(2-3):175-82.

2. Lee S, et al. J Med Chem. 2005 Apr 21;48(8):2882-91.

3. Kim MJ, et al. Eur J Pharmacol. 2005 Nov 21;525(1-3):1-7.

4. Lee KS, et al. Arch Pharm Res. 2006 May;29(5):375-83.

KR-32570 (KR32570)

生物&药学活性

物理化学性质&存储条件

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KR-32570 (KR32570)

生物&药学活性

物理化学性质&存储条件

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