KPT-251 |CAS:1388841-50-6 Probechem Biochemicals

Chemical Structure : KPT-251

CAS No.: 1388841-50-6

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KPT-251 (KPT 251;KPT251)

货号: PC-61270Not For Human Use, Lab Use Only.

KPT-251 (KPT251) is a small-molecule, selective inhibitor of nuclear export (CRM1 inhibitor, SINE) that exhibits potent antileukemic activity.

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25 mg	￥3880	In stock
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生物&药学活性

KPT-251 (KPT251) is a small-molecule, selective inhibitor of nuclear export (CRM1 inhibitor, SINE) that exhibits potent antileukemic activity.
KPT-251 induces apoptosis at nanomolar concentrations in a panel of human AML cell lines with negligible toxicity to normal hematopoietic cells.

物理化学性质&存储条件

分子量	375.23
分子式	C14H7F6N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(1Z)-2-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]ethenyl]-1,3,4-oxadiazole

参考文献

1. Etchin J, et al. Leukemia. 2013 Jan;27(1):66-74.

2. Salas Fragomeni RA, et al. Mol Cancer Ther. 2013 Jul;12(7):1171-9.

3. Cheng Y, et al. Mol Cancer Ther. 2014 Mar;13(3):675-86.

KPT-251 (KPT 251;KPT251)

生物&药学活性

物理化学性质&存储条件

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KPT-251 (KPT 251;KPT251)

生物&药学活性

物理化学性质&存储条件

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