KPB82

Chemical Structure : KPB82

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货号: PC-28460Not For Human Use, Lab Use Only.

KPB82 is a potent and selective, competitive Alkaline ceramidase 2 (ACER2) inhibitor with IC50 of 190 nM, displaying minimal activity against ACER1, ACER3, ASAH1, or ASAH2.

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生物&药学活性

KPB82 is a potent and selective, competitive Alkaline ceramidase 2 (ACER2) inhibitor with IC50 of 190 nM, displaying minimal activity against ACER1, ACER3, ASAH1, or ASAH2.
KPB82 binds ACER2 within the substrate-binding pocket, interacts with catalytical amino acid residues of ACER2.
KPB82 does not inhibit nCDase and aCDase with IC50 of >100 uM.
KPB82 inhibits ACER2-mediated cytotoxicity of doxorubicin by inhibiting SPH generation in tumor and normal cells.

物理化学性质&存储条件

分子量	383.59
分子式	C21H37NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]dodecane-1-sulfonamide

参考文献

1. Devi A, et al. bioRxiv [Preprint]. 2026 Oct 2:2026.09.29.754712.

KPB82

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物理化学性质&存储条件

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KPB82

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