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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-Akt-KP372-1
KP372-1

Chemical Structure : KP372-1

CAS No.: 1374996-60-7

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KP372-1

货号: PC-25404Not For Human Use, Lab Use Only.

KP372-1 is a small molecule Akt inhibitor, blocks signalling through the PI3K pathway and inhibits cell proliferation while inducing apoptosis of thyroid cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KP372-1 is a small molecule Akt inhibitor, blocks signalling through the PI3K pathway and inhibits cell proliferation while inducing apoptosis of thyroid cancer cells.
KP372-1 blocks signalling downstream of Akt in thyroid tumour cells, leading to inhibition of cell proliferation and increased apoptosis.
KP372-1 blocked the activation of Akt, inhibited head and neck cancer cell proliferation, and induced apoptosis and anoikis in several HNSCC cell lines.
KP372-1 decreased the phosphorylation of the S6 ribosomal (Ser240/244) protein, which is a downstream target of Akt.
KP372-1 directly inhibited the kinase activity of AKT, PDK1, and FLT3 in a concentration-dependent manner.
KP372-1 markedly decreased the colony-forming ability of primary AML samples (IC50<200 nM) with minimal cytotoxic effects on normal progenitor cells.

物理化学性质&存储条件

分子量 448.36
分子式 C20H8N12O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one, compd. with 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one (1:1)

参考文献

1. Mandal M, et al. Br J Cancer. 2005 May 23;92(10):1899-905.

2. Mandal M, et al. Oral Oncol. 2006 Apr;42(4):430-9.

3. Zeng Z, et al. Cancer Res. 2006 Apr 1;66(7):3737-46.

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