KP-1019 |CAS:124875-20-3 Probechem Biochemicals

Chemical Structure : KP-1019

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KP-1019 (FFC14A;NSC-666158;KP1019 )

货号: PC-60225Not For Human Use, Lab Use Only.

A ruthenium complex anticancer agent that is useful for metastatic tumors and cis-platin resistant tumors.

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生物&药学活性

A ruthenium complex anticancer agent that is useful for metastatic tumors and cis-platin resistant tumors; dose dependently inhibites ATPase activity of P-glycoprotein (P-gp) with Ki of 31 uM; potently blocks P-glycoprotein-mediated rhodamine 123 efflux under serum-free conditions (EC50=8 uM); induces DNA damage, leading to cell cycle delay and cell death in Saccharomyces cerevisiae.

Solid Tumors

Phase 1 Discontinued

物理化学性质&存储条件

分子量	598.3
分子式	C21H19Cl4N6Ru
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ruthenate(1-), tetrachlorobis(1H-indazole-κN2)-, (OC-6-11)-, hydrogen, compd. with 1H-indazole (1:1:1)

参考文献

1. Hummer AA, et al. J Med Chem. 2013 Feb 14;56(3):1182-96.

2. Heffeter P, et al. J Pharmacol Exp Ther. 2005 Jan;312(1):281-9.

3. Stevens SK, et al. Mol Pharmacol. 2013 Jan;83(1):225-34.

KP-1019 (FFC14A;NSC-666158;KP1019 )

生物&药学活性

物理化学性质&存储条件

参考文献

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KP-1019 (FFC14A;NSC-666158;KP1019 )

生物&药学活性

物理化学性质&存储条件

参考文献

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