KOTX1 | ALDH1A3 inhibitor | Probechem Biochemicals

Chemical Structure : KOTX1

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KOTX1 (ALDH1A3 inhibitor KOTX1)

货号: PC-20212Not For Human Use, Lab Use Only.

KOTX1 is a potent, selective and reversible ALDH1A3 inhibitor with IC50 of 5.14 nM by Aldefluor assay in A375 cells.

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生物&药学活性

KOTX1 is a potent, selective and reversible ALDH1A3 inhibitor with IC50 of 5.14 nM by Aldefluor assay in A375 cells.
KOTX1 does not inhibit the closely related ALDH1A1 or ALDH2 isoforms.
KOTX1 (40 mg/kg/day, oral gavage, 1 week) inhibits ALDH1A3 activity and restores β-cell function and maturity in db/db mice.
KOTX1 IC50 is 10-fold lower in human A375 cells than in diabetic mouse islets.
KOTX1 (40 mg/kg/day, oral gavage) improved glucose control, increased insulin secretion, and enhanced glucose tolerance in male DIO mice.

物理化学性质&存储条件

分子量	313.33
分子式	C17H16FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-ethyl-N-(7-fluoro-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)isonicotinamide

参考文献

1. Jinsook Son, et al. Nat Commun. 2023 Feb 2;14(1):558.

KOTX1 (ALDH1A3 inhibitor KOTX1)

生物&药学活性

物理化学性质&存储条件

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KOTX1 (ALDH1A3 inhibitor KOTX1)

生物&药学活性

物理化学性质&存储条件

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