KO-947 |CAS:1695533-89-1 Probechem Biochemicals

Chemical Structure : KO-947

CAS No.: 1695533-89-1

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KO-947 (KO 947;KO947)

货号: PC-61978Not For Human Use, Lab Use Only.

KO-947 (KO947) is a potent and selective inhibitor of ERK1/2 kinase in biochemical, cellular and in vivo antitumor activity assays.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
50 mg	￥5480	In stock
100 mg		Get quote

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生物&药学活性

KO-947 (KO947) is a potent and selective inhibitor of ERK1/2 kinase in biochemical, cellular and in vivo antitumor activity assays.
KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling, including mutations in BRAF, NRAS or KRAS, at low nanomolar concentrations.

物理化学性质&存储条件

分子量	355.401
分子式	C21H17N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-benzyl-3-(pyridin-4-yl)-1,5,6,8-tetrahydro-7H-pyrazolo[4,3-g]quinazolin-7-one

参考文献

1. Burrows F, et al. Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5.

KO-947 (KO 947;KO947)

生物&药学活性

物理化学性质&存储条件

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KO-947 (KO 947;KO947)

生物&药学活性

物理化学性质&存储条件

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