KNa1.1 inhibitor 31

首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-KNa1.1 inhibitor 31

Chemical Structure : KNa1.1 inhibitor 31

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货号: PC-73241Not For Human Use, Lab Use Only.

KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).
KNa1.1 inhibitor 31 reduced seizures and interictal spikes in a mouse model of KCNT1 GoF.

物理化学性质&存储条件

分子量	434.302
分子式	C16H12F6N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-methyl-3-(trifluoromethyl)-N-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)-1,2,4-oxadiazol-5-yl)ethyl)-1H-pyrazole-5-carboxamide

参考文献

1. Andrew M Griffin, et al. ACS Med Chem Lett. 2021 Mar 9;12(4):593-602.

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