KNK437 | HSP synthesis inhibitor | Probechem Biochemicals

Chemical Structure : KNK437

CAS No.: 218924-25-5

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KNK437 (KNK-437)

货号: PC-42056Not For Human Use, Lab Use Only.

KNK437 is an inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells.

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10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

KNK437 is an inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells.
KNK437 inhibits the acquisition of thermotolerance as developed by sodium arsenite, also inhibits at mRNA levels.
KNK437 shows no antitumor effects and does not increase the thermosensitivity of nontolerant tumors in vivo (up to 200 mg/kg).

物理化学性质&存储条件

分子量	245.2307
分子式	C13H11NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	1-Pyrrolidinecarboxaldehyde, 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-

参考文献

1. Yokota S, et al. Cancer Res. 2000 Jun 1;60(11):2942-8.

2. Koishi M, et al. Clin Cancer Res. 2001 Jan;7(1):215-9.

3. Guo F, et al. Cancer Res. 2005 Nov 15;65(22):10536-44.

KNK437 (KNK-437)

生物&药学活性

物理化学性质&存储条件

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KNK437 (KNK-437)

生物&药学活性

物理化学性质&存储条件

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