KNI-1657 |CAS: 2236594-14-0 Probechem Biochemicals

Chemical Structure : KNI-1657

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KNI-1657 (KNI1657)

货号: PC-35156Not For Human Use, Lab Use Only.

KNI-1657 (KNI1657) is a highly potent HIV-1 protease inhibitor (97% inhibition at 1 nM) with high sensitivity against lopinavir/ritonavir- or darunavir-resistant strains.

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生物&药学活性

KNI-1657 (KNI1657) is a highly potent HIV-1 protease inhibitor (97% inhibition at 1 nM) with high sensitivity against lopinavir/ritonavir- or darunavir-resistant strains.
KNI-1657 inhibits wild-type HIV-1 (pNL4-3) and LPV-resistant strain A17 with IC50 of <3 and 25 nM, respectively.

物理化学性质&存储条件

分子量	756.915
分子式	C41H48N4O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(2,6-dimethylbenzyl)-3-((2S,3S)-2-hydroxy-3-((S)-2-(7-methoxybenzofuran-2-carboxamido)-2-((R)-tetrahydrofuran-3-yl)acetamido)-4-phenylbutanoyl)-5,5-dimethylthiazolidine-4-carboxamide

参考文献

1. Hidaka K, et al. J Med Chem. 2018 May 31. doi: 10.1021/acs.jmedchem.7b01709.

KNI-1657 (KNI1657)

生物&药学活性

物理化学性质&存储条件

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KNI-1657 (KNI1657)

生物&药学活性

物理化学性质&存储条件

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