KN-62 (KN62) | CaMK II inhibitor, P2X7 antagonist | Probechem Biochemicals

Chemical Structure : KN-62

CAS No.: 127191-97-3

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KN-62 (KN62, CaMK II inhibitor KN62)

货号: PC-43468Not For Human Use, Lab Use Only.

KN-62 (KN62) is a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK II) with Ki of 900 nM for rat brain CaMK II, also is a potent, noncompetitive antagonist of P2X7 receptor with IC50 of 15 nM in HEK293 cells.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

KN-62 (KN62) is a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK II) with Ki of 900 nM for rat brain CaMK II, also is a potent, noncompetitive antagonist of P2X7 receptor with IC50 of 15 nM in HEK293 cells.
KN-62 potently antagonizes ATP-stimulated Ba2+ influx into fura-2 loaded human lymphocytes with IC50 of 12.7 nM, inhibits ATP-stimulated ethidium+ uptake with IC50 of 13.1 nM.
KN-62 causes hypertension and tachycardia in rats, associated with the diminished rate of GABA release in cerebrospinal fluid.

物理化学性质&存储条件

分子量
分子式	C38H35N5O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester

参考文献

1. Tokumitsu H, et al. J Biol Chem. 1990 Mar 15;265(8):4315-20.

2. Ishikawa N, et al. J Pharmacol Exp Ther. 1990 Aug;254(2):598-602.

3. Ito I, et al. Neurosci Lett. 1991 Jan 2;121(1-2):119-21.

4. Gargett CE, et al. Br J Pharmacol. 1997 Apr;120(8):1483-90.

KN-62 (KN62, CaMK II inhibitor KN62)

生物&药学活性

物理化学性质&存储条件

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KN-62 (KN62, CaMK II inhibitor KN62)

生物&药学活性

物理化学性质&存储条件

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