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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-KMU-11342
KMU-11342

Chemical Structure : KMU-11342

CAS No.: 2901875-71-4

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KMU-11342

货号: PC-27384Not For Human Use, Lab Use Only.

KMU-11342 is a novel multi-protein kinase inhibitor, inhibits inflammatory protein kinases including IKKα(h), IKKβ(h), JAK1(h), JAK2(h), JAK3(h), MAPK1(h), JNK3(h), TAK1(h), and TYK2(h) with IC50 of <1 uM, mitigates LPS-mediated inflammatory responses in THP-1 cells by inhibiting the activation of NLRP3 inflammasome.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KMU-11342 is a novel multi-protein kinase inhibitor, inhibits inflammatory protein kinases including IKKα(h), IKKβ(h), JAK1(h), JAK2(h), JAK3(h), MAPK1(h), JNK3(h), TAK1(h), and TYK2(h) with IC50 of <1 uM, mitigates LPS-mediated inflammatory responses in THP-1 cells by inhibiting the activation of NLRP3 inflammasome.

物理化学性质&存储条件

分子量 372.43
分子式 C21H20N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-3-((1H-imidazol-5-yl)methylene)-5-(6-(cyclopentylamino)pyrazin-2-yl)indolin-2-one

参考文献

1. Baek HS, et al. Inflamm Res. 2024 Aug;73(8):1371-1391.

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