KMN-159 | EP4 agonist | Probechem Biochemicals

Chemical Structure : KMN-159

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KMN-159 (KMN159)

货号: PC-49034Not For Human Use, Lab Use Only.

KMN-159 is a potent, selective small-molecule full agonist of the prostaglandin E2 type 4 (EP4) receptor with Ki of 0.24 nM (rEP4) and EC50 of 10.6 nM in the BMC ALP assays, with no affinity for EP2 (Ki>10,000 nM).

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生物&药学活性

KMN-159 is a potent, selective small-molecule full agonist of the prostaglandin E2 type 4 (EP4) receptor with Ki of 0.24 nM (rEP4) and EC50 of 10.6 nM in the BMC ALP assays, with no affinity for EP2 (Ki>10,000 nM).
KMN-159 demonstrates the ability to stimulate osteoblastic differentiation in vitro in total rat bone marrow from both sexes and from young and old rats as measured by induction of ALP enzyme activity, mineralized nodule formation, and osteoblast phenotype marker gene expression.
KMN-159 can increase the rate of defect closure significantly over vehicle to that equivalent to rhBMP-2 in a rat calvarial defect model.

物理化学性质&存储条件

分子量	399.479
分子式	C21H31F2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((R)-3,3-difluoro-5-((3S,4S,E)-3-hydroxy-4-methylnon-1-en-6-yn-1-yl)-2-oxopyrrolidin-1-yl)heptanoic acid

参考文献

1. Barrett SD, et al. J Med Chem. 2019 May 9;62(9):4731-4741.

2. Owen TA, et al. Gene. 2020 Jul 20;748:144668.

KMN-159 (KMN159)

生物&药学活性

物理化学性质&存储条件

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KMN-159 (KMN159)

生物&药学活性

物理化学性质&存储条件

参考文献

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