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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-CFTR-KM11060
KM11060

Chemical Structure : KM11060

CAS No.: 774549-97-2

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KM11060 (KM 11060, KM-11060)

货号: PC-45770Not For Human Use, Lab Use Only.

KM11060 is a potent corrector of the F508del-CFTR trafficking defect that partially restores F508del trafficking and increases maturation significantly in BHK cells (10 nM for 24 h or 10 uM for 2 h).

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25 mg ￥1180 In stock
50 mg ￥1880 In stock
100 mg ￥2980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KM11060 is a potent corrector of the F508del-CFTR trafficking defect that partially restores F508del trafficking and increases maturation significantly in BHK cells (10 nM for 24 h or 10 uM for 2 h).
KM11060 also can significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice.

物理化学性质&存储条件

分子量 422.3282
分子式 C19H17Cl2N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-

参考文献

1. Robert R, et al. Mol Pharmacol. 2008 Feb;73(2):478-89.

2. Loo TW, et al. Biochem Pharmacol. 2012 Feb 1;83(3):345-54.

3. Wu H, et al. PLoS One. 2014 Mar 26;9(3):e93003.

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