KM04794 | UPR inhibitor | Probechem Biochemicals

Chemical Structure : KM04794

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KM04794 (KM 04794, KM-04794)

货号: PC-72838Not For Human Use, Lab Use Only.

KM04794 (KM-04794) is a chemical chaperone-like small molecule modulator of endoplasmic reticulum (ER) proteostasis and alleviates ER stress, inhibits UPR signaling with IC50 of 10 uM.

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生物&药学活性

KM04794 (KM-04794) is a chemical chaperone-like small molecule modulator of endoplasmic reticulum (ER) proteostasis and alleviates ER stress, inhibits UPR signaling with IC50 of 10 uM.
KM04794 accumulates in the ER and directly interacts amd binds to with the ER molecular chaperone BiP, KM04794 inhibits the aggregation of GAPDH in cooperation with BiP.
KM04794 suppresses Tm-induced phosphorylation of IRE1 and PERK and induction of XBP1 and
ATF4 in the MIN6m9 pancreatic β cell line.
KM04794 suppresses UPR activation induced by brefeldin A.
KM04794 alleviates ER protein aggregation and ER stress-induced cell death, and mutant insulin-induced ER stress.
KM04794 increases intracellular and secreted insulin levels in pancreatic β cells.

物理化学性质&存储条件

分子量	494.913
分子式	C23H18ClF3N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-(2-(2-((4-chlorobenzyl)thio)phenoxy)acetyl)-3-(trifluoromethyl)benzohydrazide

参考文献

1. Masato Miyake, et al. Cell Chem Biol. 2022 Feb 7;S2451-9456(22)00002-2.

KM04794 (KM 04794, KM-04794)

生物&药学活性

物理化学性质&存储条件

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KM04794 (KM 04794, KM-04794)

生物&药学活性

物理化学性质&存储条件

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