KLH45 | DDHD2 inhibitor | Probechem Biochemicals

Chemical Structure : KLH45

CAS No.: 1632236-44-2

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KLH45 (DDHD2 inhibitor KLH45)

货号: PC-38539Not For Human Use, Lab Use Only.

KLH45 is a potent, selective and in vivo-active serine hydrolase DDHD2 inhibitor with IC50 of 1.3 nM, shows excellent selectivity against other serine hydrolases with exception of ABHD6.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

KLH45 is a potent, selective and in vivo-active serine hydrolase DDHD2 inhibitor with IC50 of 1.3 nM, shows excellent selectivity against other serine hydrolases with exception of ABHD6.
KLH45 inactivated DDHD2 and ABHD6 in Neuro2A cells with low nanomolar in situ potency (<10 nM).
KLH45 (25 nM, 4 h) completely inactivated DDHD2 (>95% inhibition) in Neuro2A cells and showed no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6.
KLH45 (20 mg/kg) promotes elevations triglycerides (TAGs) in the mouse brain.

物理化学性质&存储条件

分子量	458.485
分子式	C24H25F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide

参考文献

1. Jordon M Inloes, et al. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14924-9.

KLH45 (DDHD2 inhibitor KLH45)

生物&药学活性

物理化学性质&存储条件

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KLH45 (DDHD2 inhibitor KLH45)

生物&药学活性

物理化学性质&存储条件

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