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首页-小分子抑制剂&激动剂-Others-Other Targets-KL201
KL201

Chemical Structure : KL201

CAS No.: 302939-48-6

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KL201 (KL 201, KL-201)

货号: PC-38276Not For Human Use, Lab Use Only.

KL201 (KL201) is an isoform-selective modulator of Cryptochrome 1 (CRY1), stabilize CRY1 but not CRY2.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg ￥5780 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KL201 (KL201) is an isoform-selective modulator of Cryptochrome 1 (CRY1), stabilize CRY1 but not CRY2.
KL201 did not affect CKId, CKIa, or CK2 activities.
KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex.
KL201 also repressed mRNA levels of Per2 and another CLOCK-BMAL1 target gene Dbp in wildtype fibroblasts, and the repression appeared to be reduced in Cry1 knockout cells but not in Cry2 knockout cells.
KL201 lengthened the period of circadian rhythms (Log EC2h=-5.63) in cells and tissues.

物理化学性质&存储条件

分子量 388.283
分子式 C17H14BrN3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-bromo-N-(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)benzamide

参考文献

1. Simon Miller, et al. Cell Chem Biol. 2020 Sep 17;27(9):1192-1198.e5.

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