KL001 |CAS:309928-48-1 Probechem Biochemicals

Chemical Structure : KL001

CAS No.: 309928-48-1

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KL001 (KL-001;KL 001)

货号: PC-36022Not For Human Use, Lab Use Only.

KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.

规格	价格	库存
2 mg (Free Sample)	￥280	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.
KL001 prevents SCFFBXL3-mediated ubiquitination and degradation of CRY, resulting in lengthening of the circadian period, interacts directly with CRY1 and CRY2 and stabilizes CRY proteins.
KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes.
KL001 is the first-in-class cryptochrome-targeting circadian modulator and substrate-targeting ubiquitination antagonist.

物理化学性质&存储条件

分子量	398.477
分子式	C21H22N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide

参考文献

1. Hirota T, et al. Science. 2012 Aug 31;337(6098):1094-7.

2. Nangle S, et al. Cell Res. 2013 Dec;23(12):1417-9.

3. St John PC, et al. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):2040-5.

4. Oshima T, et al. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7193-7.

KL001 (KL-001;KL 001)

生物&药学活性

物理化学性质&存储条件

参考文献

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KL001 (KL-001;KL 001)

生物&药学活性

物理化学性质&存储条件

参考文献

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