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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Glucose Transporter (GLUT)-KL-11743
KL-11743

Chemical Structure : KL-11743

CAS No.: 1369452-53-8

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KL-11743 (KL11743)

货号: PC-72556Not For Human Use, Lab Use Only.

KL-11743 (KL11743) is a potent, selective, orally bioavailable inhibitor of class I glucose transporters with IC50 of 115/137/90/68 nM for GLUT1/2/3/4, respectively.

规格 价格 库存 数量
2 mg ￥1580 In stock
5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KL-11743 (KL11743) is a potent, selective, orally bioavailable inhibitor of class I glucose transporters (GLUT) with IC50 of 115/137/90/68 nM for GLUT1/2/3/4, respectively.
KL-11743 demonstrated no inhibitory activity at 10 uM against hexokinase.
KL-11743 inhibited both glucose consumption, lactate secretion, and 2DG transport in HT-1080 fibrosarcoma cells, with IC50 values of 228, 234, and 87 nM, respectively, and fully inhibited glycolytic ATP production in oligomycin-treated cells with an IC50 of 127 nM.
KL-11743 had minimal off-target activity in a panel of 85 high-liability receptors and transporters and 411 human kinases.
KL-11743 dose-dependently inhibits HT-1080 cells growth (IC50=667 nM), suppresses glucose metabolism and induces redox and energetic stress.
KL-11743 inhibits the growth of TCA cycle-deficient cancers in vitro and in vivo.

物理化学性质&存储条件

分子量 522.609
分子式 C30H30N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Acetamide, 2-[3-[6-ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-

参考文献

1. Kellen Olszewski, et al. Cell Chem Biol. 2021 Oct 22;S2451-9456(21)00441-4.

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