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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-KKL-55
KKL-55

Chemical Structure : KKL-55

CAS No.: 639048-45-6

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KKL-55 (KKL55)

货号: PC-21141Not For Human Use, Lab Use Only.

KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity.
KKL-55 specifically inhibits EF-Tu activity in trans-translation without affecting its activity in normal translation.
KKL-55 binds domain 3 of EF-Tu, alters EF-Tu binding to tmRNA.

物理化学性质&存储条件

分子量 265.70
分子式 C11H12ClN5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-chloro-N-(1-propyl-1H-tetrazol-5-yl)benzamide

参考文献

1. Neeraja Marathe, et al. mBio. 2023 Sep 8;e0146123. doi: 10.1128/mbio.01461-23.

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