KKL-40 |CAS:865285-47-8 Probechem Biochemicals

Chemical Structure : KKL-40

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KKL-40 (KKL40)

货号: PC-61266Not For Human Use, Lab Use Only.

A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.

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生物&药学活性

KKL-40 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
KKL-40 exhibited exceptional antimicrobial activity against both attenuated (LVS) and fully virulent strains of F. tularensis (Schu S4) in vitro with MIC of 0.12 and 0.44 ug/mL, respectively.
KKL-40 arrests intracellular growth of F. tularensis during all stages of infection, does not affect macrophage viability or function.

物理化学性质&存储条件

分子量	351.261
分子式	C16H9F4N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide

参考文献

1. Goralski TD, et al. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82.

KKL-40 (KKL40)

生物&药学活性

物理化学性质&存储条件

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KKL-40 (KKL40)

生物&药学活性

物理化学性质&存储条件

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