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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-IRE1-KIRA6
KIRA6

Chemical Structure : KIRA6

CAS No.: 1589527-65-0

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KIRA6 (KIRA 6)

货号: PC-47079Not For Human Use, Lab Use Only.

KIRA6 is a potent, ATP-competitive type II IRE1α kinase inhibitor, allosterically inhibits IRE1α RNase kinase activity with IC50 of 0.6 uM and prevents oligomerization.

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25 mg ￥2780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KIRA6 is a potent, ATP-competitive type II IRE1α kinase inhibitor, allosterically inhibits IRE1α RNase kinase activity with IC50 of 0.6 uM and prevents oligomerization.
KIRA6 inhibits IRE1α in vivo and to promote cell survival under ER stress, preserve photoreceptor functional viability in rat models of ER stress-induced retinal degeneration.

物理化学性质&存储条件

分子量 518.5
分子式 C28H25F3N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[4-[8-amino-3-(1,1-dimethylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoromethyl)phenyl]-urea

参考文献

1. Ghosh R, et al. Cell. 2014 Jul 31;158(3):534-48.

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