KIRA-8 |CAS:1630086-20-2 Probechem Biochemicals

Chemical Structure : KIRA-8

CAS No.: 1630086-20-2

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KIRA-8 (AMG-18)

货号: PC-36004Not For Human Use, Lab Use Only.

KIRA-8 (AMG-18) is a highly potent, monoselective IRE1α kinase inhibitor with IC50 of 5.9 nM.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

KIRA-8 (AMG-18) is a highly potent, monoselective IRE1α kinase inhibitor with IC50 of 5.9 nM.
KIRA-8 demonstrates higher potency than KIRA7 in inhibiting XBP1 splicing in the alveolar epithelial cell line MLE12, attenuates bleomycin-induced increases in lung weight and hydroxyproline, and decreases mRNA expression of collagen 1A1 and fibronectin in murine model of pulmonary fibrosis.

物理化学性质&存储条件

分子量	601.122
分子式	C31H29ClN6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide

参考文献

1. Thamsen M, et al. PLoS One. 2019 Jan 9;14(1):e0209824.

2. Morita S, et al. Cell Metab. 2017 Apr 4;25(4):883-897.e8.

KIRA-8 (AMG-18)

生物&药学活性

物理化学性质&存储条件

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KIRA-8 (AMG-18)

生物&药学活性

物理化学性质&存储条件

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