KIRA-7 |CAS:1937235-76-1 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-IRE1-KIRA-7

Chemical Structure : KIRA-7

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KIRA-7 (KIRA7)

货号: PC-36003Not For Human Use, Lab Use Only.

KIRA-7 is a small molecule inhibitor of IRE1α kinase/Rnase with IC50 of 0.11/0.22 uM, allosterically inhibits IRE1α RNase activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KIRA-7 is a small molecule inhibitor of IRE1α kinase/Rnase with IC50 of 0.11/0.22 uM, allosterically inhibits IRE1α RNase activity.
KIRA-7 reverses bleomycin-induced fibrosis when given 2 weeks after bleomycin exposure in vivo.

物理化学性质&存储条件

分子量	466.52
分子式	C27H23FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(8-amino-3-(1-methylcyclopropyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-fluorophenyl)urea

参考文献

1. Thamsen M, et al. PLoS One. 2019 Jan 9;14(1):e0209824.

2. Feldman HC, et al. ACS Chem Biol. 2016 Aug 19;11(8):2195-205.

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KIRA-7 (KIRA7)

生物&药学活性

物理化学性质&存储条件

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KIRA-7 (KIRA7)

生物&药学活性

物理化学性质&存储条件

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