KIO-100 | DHODH inhibitor | Probechem Biochemicals

Chemical Structure : KIO-100

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KIO-100 (PP-001)

货号: PC-49419Not For Human Use, Lab Use Only.

KIO-100 (PP-001) is a novel potent, specific small molecule inhibitor of DHODH with IC50 of <4 nM, 150-fold higher potency than leflunomide (IC50 of 650 nM).

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生物&药学活性

KIO-100 (PP-001) is a novel potent, specific small molecule inhibitor of DHODH with IC50 of <4 nM, 150-fold higher potency than leflunomide (IC50 of 650 nM).
KIO-100 (PP-001) does not inhibit tyrosine kinase or cause hepatotoxicity like leflunomide since, like other small molecule DHODH inhibitors, KIO-100 (PP-001) does not need to be converted from a prodrug to its active form in the liver.
KIO-100 (PP-001) reduces the proliferation in a dose-dependent manner in human peripheral blood lymphocytes (PBL), also inhibits cytokine/chemokine secretion of human lymphocytes.
KIO-100 (PP-001) efficiently suppresses rat uveitis in a preventive as well as therapeutic mode.

物理化学性质&存储条件

分子量	479.325
分子式	C19H8F7NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((2,3,5,6-tetrafluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)carbamoyl)thiophene-2-carboxylic acid

参考文献

1. Diedrichs-Möhring M, et al. J Neuroinflammation. 2018 Feb 21;15(1):54.

2. Thurau S, et al. Front Med (Lausanne). 2022 Oct 17;9:1023224.

KIO-100 (PP-001)

生物&药学活性

物理化学性质&存储条件

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KIO-100 (PP-001)

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