KIN001-266 | Tpl2/MAP3K8 inhibitor | Probechem Biochemicals

Chemical Structure : KIN001-266

CAS No.: 915363-56-3

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KIN001-266 (Tpl2 inhibitor 34, MAP3K8-IN-34)

货号: PC-45794Not For Human Use, Lab Use Only.

Tpl2-IN-34 is a potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥3580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KIN001-266 (Tpl2-IN-34) is a potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.
Tpl2-IN-34 dispalys 6875-fold selectivity over EGFR. P38, Src, CAMKII, MK2, PKA, and PKC (IC50>10 uM).
Tpl2-IN-34 inhibits LPS-induced TNF-α production in whole blood with IC50 of 0.3 uM.
Tpl2-IN-34 shows good efficacy in inhibiting TNF-alpha production in a LPS-stimulated rat inflammation model; orally active.

物理化学性质&存储条件

分子量	539.4347
分子式	C26H25Cl2FN8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-

参考文献

1. Wu J, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.

KIN001-266 (Tpl2 inhibitor 34, MAP3K8-IN-34)

生物&药学活性

物理化学性质&存储条件

参考文献

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KIN001-266 (Tpl2 inhibitor 34, MAP3K8-IN-34)

生物&药学活性

物理化学性质&存储条件

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